this review gives an overview of our recent findings and developments in research on brain mechanisms of morphine reward from studies using the place preference conditioning paradigm. intracranial place conditioning methodology has become a valuable and firmly established and very widely used tool in behavioural pharmacology and drug reward mechanisms. several studies have established that morp...

background: previous studies have confirm the effects of water extract of crocus sativus on the euphoric and behavioral properties of morphine in mice. objective: in the present study, the effects of intra-accumbal administration of alcohol extract of crocus sativus stigma on the acquisition and expression of morphine-induced conditioned place preference (cpp) in male wistar rats (250-300 g) we...

introduction: topiramate is a newly anti-convulsant drug, which acts as nmda glutamate receptor antagonist as well as the gabab receptor agonist. it is used for physical dependence to opioids as well as cocaine, nicotine, alcohol and ecstasy dependence. in the present study attempts were made to further identification of the effects of topiramate on the acquisition and expression of morphine-in...

introduction: activation of n-methyl-d-aspartate (nmda) glutamate receptors in the nucleus accumbens is a component of drug-induced reward mechanism. in addition, nmda receptors play a major role in brain reward system and activation of these receptors can change firing pattern of dopamine neurons. blockade of glutamatergic neurotransmission reduces the expression of conditioned place preferenc...

objective: in the present study, the effects of aqueous saffron extract (crocus sativus l.) on the acquisition and reinstatement of morphine-induced conditioned place preference (cpp) in mice were investigated. materials and methods: subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. intraperitoneal administration of aqueous extract (40 and 80 mg/kg for ...

downward phase of dose-response morphine converted u shape curve was chosen as a base for investigating the effects of different doses of naloxone (0.05-0.4 mg/kg) on morphine reward/aversion properties using place preference method. first, male wistar rats (200-220 g) were received morphine (1-7.5 mg/kg) for place conditioning and marginal dose of morphine (5 mg/kg) calculated by graphpad soft...

Prior studies using mice have shown that scent marks are an important source of information and can cause behavioural changes in other individuals. Studies have also shown that scent marks in the environment can affect the outcome of social interactions between mice. We used conditioned place preference tests to investigate whether CD-1 male mice (Mus musculus) are reinforced by olfactory cues ...

Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated. Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for...

objective: it has been shown that berberine, a major component of berberis vulgaris extract, modulates the activity of several neurotransmitter systems including dopamine (da) and n-methyl-d-aspartate (nmda) contributing to rewarding and reinforcing effects of morphine. drug craving and relapsing even after a long time of abstinence therapy are the most important problems of addiction. in the p...

the effect of hypericin on the expression of morphine-induced conditioned place preference (cpp) was investigated and compared with the effect of the synthetic antidepressants. the cpp paradigms took place over six days using an unbiased procedure. the results demonstrate that intra-peritoneal (ip) injection of morphine sulfate (2.5, 5 and 10 mg/kg) significantly induce the cpp in rat. intra-pe...